Management of xerostomia using chlorine dioxide mouthwash in post-surgical and chemotherapy breast cancer patient with aromatase inhibitor treatment (anastrazole)

Ronden Perwiradinata(1), Desiana Radithia(2), Adiastuti Endah(3), Bagus Soebadi(4),

(1) Department of Oral Medicine, Faculty of Dental Medicine, Airlangga Universit, Surabaya, Indonesia
(2) Department of Oral Medicine, Faculty of Dental Medicine, Airlangga Universit, Surabaya, Indonesia
(3) Department of Oral Medicine, Faculty of Dental Medicine, Airlangga Universit, Surabaya, Indonesia
(4) Department of Oral Medicine, Faculty of Dental Medicine, Airlangga Universit, Surabaya, Indonesia


Objective: A 59-year-old woman with complaints of dry mouth, often feel thirsty, pain when swallowing, chapped lips, bleeding gums and bad breath. The patient had a history of breast cancer, underwent surgery and chemotherapy in 2010. The patient consumed 1 mg of Aromatase Inhibitors (AIs) tablets a day for 9 years.

Methods: Patient underwent depression, anxiety and Stress Scale (DASS) questionnaire (Depression: normal; Anxiety: mild; and Stress: mild) and sialometry test (draining method) <0.1 ml/minute. Patient was diagnosed with xerostomia then instructed to use chlorine dioxide mouthwash 4 times a day. Management included anamnesis, clinical and laboratory examination: Complete Blood Count (CBC); Diabetic Profile; Lipid Profile; Renal Function Profile; and Tumour Marker test.

Results: Patient’s sialometry test results in 1st, 2nd, 3rd and 4th visit are: 0.1ml/minute; 0.6ml/minute; 1.4ml/minute and 1.8ml/minute.

Conclusion: Dentist has important role to evaluate and treat oral condition for optimal and comprehensive breast cancer treatment. Chlorine dioxide mouthwash is clinically proven to stimulate salivary gland in treating xerostomia.


Aromatase inhibitor, Breast Neoplasms, Chlorine dioxide mouthwash, Xerostomia

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